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GNA12 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/G12/GTP complex (EDNRA-EDN1-GNA12) → Rho family GTPase (RAC1/RHOA/CDC42) (modification, activates)
  Gohla et al., J Biol Chem 1999, Nishida et al., J Biol Chem 2007
• NCI Pathway Database Endothelins: ETA receptor/Endothelin-1/G12/GTP complex (EDNRA-EDN1-GNA12) → Rho Family GTPase-active (RHOA/CDC42/RAC1) (modification, activates)
  Gohla et al., J Biol Chem 1999, Nishida et al., J Biol Chem 2007

Text-mined interactions from Literome

Yamaguchi et al., J Biol Chem 2001 : Constitutively active RhoA, RhoA ( V14 ), or constitutively active Galpha(12) induced endogenous RhoA activation inhibited the NGF induced Rac1 activation without any effect on the NGF induced extracellular signal regulated kinase activation
Bottero et al., Virology 2009 : These activities were pertussis toxin independent, did not involve Rho and Rac-GTPases and involved the heterotrimeric G protein subunits Galpha12 and Galphaq
Collins et al., J Biol Chem 1996 : In contrast, dominant negative Rac ( N17Rac1 ) inhibited JNK activation by Galpha12 in HEK293 cells as well as three other cell lines