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HGF — RB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RB1 → HGF (increases) Ma et al., Br J Cancer 2007*
  Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...

Text-mined interactions from Literome

Leshem et al., J Cell Physiol 2002 : A constitutively active pRb mutant blocked HGF dependent pRb phosphorylation and transactivation of E2F1 and increased cell proliferation ... HGF mediated pRb phosphorylation was reversed by ectopic expression of p27, but neither the myogenic regulatory factor, MEF2, nor the myogenic inhibitory protein Twist had that effect
MacEwen et al., Clin Exp Metastasis 2003 (Neoplasm Metastasis...) : To further characterize the role of hepatocyte growth factor-scatter factor ( HGF-SF ) and its receptor ( c-Met ) in osteosarcoma (OS) , human OS cell lines with low ( SAOS-2 ) and high ( SAOS-LM2 ) metastatic potential, and cell lines derived from spontaneous canine OS were studied