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STAT5A — TYK2
Pathways - manually collected, often from reviews:
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BioCarta il22 soluble receptor signaling pathway:
STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B)
→
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
(modification, collaborate)
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BioCarta il22 soluble receptor signaling pathway:
IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1)
→
STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B)
(modification, activates)
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KEGG Jak-STAT signaling pathway:
JAK1/JAK2/JAK3/TYK2
→
STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6
(protein-protein, phosphorylation)
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NCI Pathway Database IL27-mediated signaling events:
STAT5A (STAT5A)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
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NCI Pathway Database IL12-mediated signaling events:
STAT5A (STAT5A)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
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NCI Pathway Database IL23-mediated signaling events:
STAT5A (STAT5A)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
Text-mined interactions from Literome
Lukashova et al., J Biol Chem 2001
:
Activation of
Tyk2 was
followed by a time dependent 2-4-fold increase in the level of tyrosine phosphorylation of signal transducers and activators of transcription 1 ( STAT1 ), STAT2, and STAT3 and a sustained 2.5-fold increase in
STAT5 tyrosine phosphorylation
Liu et al., Am J Respir Cell Mol Biol 2002
(Lung Neoplasms) :
NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of
TYK2 and JAK3, but not JAK1 or JAK2, and
induced STAT3 and
STAT5 tyrosine phosphorylation
Versteeg et al., Circ Res 2004
:
FVIIa induced
STAT5 phosphorylation was
dependent on functional G12/G13 class G proteins and Jak2 activity, but not Jak1 or
Tyk2
Nakajima et al., Int J Hematol 2006
(Disease Models, Animal...) :
We have previously shown that FLT3-ITD signals mainly through the signal transducer and activator of transcription 5 ( STAT5 ) pathway and have suggested the possible
involvement of
Tyk2 in
STAT5 activation by FLT3-ITD
Shide et al., Leuk Res 2007
(Myeloproliferative Disorders...) :
V678F
Tyk2 augmented the transcriptional activity of Stat3 and
Stat5