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PTEN — TXN
Text-mined interactions from Literome
Lee et al., J Biol Chem 2002
:
Thioredoxin co-immunoprecipitated with PTEN from cell lysates ; and incubation of cells with 2,4-dinitro-1-chlorobenzene ( an inhibitor of thioredoxin reductase )
delayed the reduction of oxidized
PTEN , whereas incubation with buthioninesulfoximine ( an inhibitor of glutathione biosynthesis ) did not
Meuillet et al., Arch Biochem Biophys 2004
:
Thioredoxin-1 binds to the C2 domain of PTEN
inhibiting PTEN 's lipid phosphatase activity and membrane binding : a mechanism for the functional loss of PTEN 's tumor suppressor activity ... The results of the study suggest that the increased levels of
Trx-1 in human tumors could
lead to functional inhibition of
PTEN tumor suppressor activity providing an additional mechanism for tumorigenesis with loss of PTEN activity
Hui et al., Proc Natl Acad Sci U S A 2008
(Insulin Resistance...) :
In the absence of Txnip, oxidative inactivation of PTEN and subsequent activation of Akt attenuated mitochondrial respiration, resulting in the accumulation of NADH, a competitive inhibitor of
thioredoxin NADPH-reductive
activation of
PTEN