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PAX2 — WNT4

Text-mined interactions from Literome

Cai et al., J Biol Chem 2002 : Activation of JNK by either upstream kinase MEKK1 or DLK or by expression of Wnt signaling proteins significantly enhances Pax2 phosphorylation in cells
Torban et al., J Biol Chem 2006 : PAX2 activates WNT4 expression during mammalian kidney development ... In this study we hypothesized that PAX2 activates expression of WNT4 , a secreted glycoprotein known to be critical for successful nephrogenesis ... PAX2 activated WNT4 promoter activity 5-fold in co-transfection assays with JTC12 cells derived from the proximal tubule ... We speculated that a key function of PAX2 is to activate WNT4 gene expression in metanephric mesenchymal cells as they differentiate to form elements of the renal tubules
Qin et al., J Am Soc Nephrol 2012 (Polycystic Kidney Diseases) : Hyperactivated Wnt signaling increased expression of the transcription factor Pax2 in the cells lining cysts