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IRF7 — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: TRAF6 → IRF7 (protein-protein, activation)
• Reactome Reaction: IRF7 → TRAF6 (reaction) Marié et al., Mol Cell Biol 2000*, Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Ning et al., Mol Cell Biol 2008, Konno et al., PloS one 2009
• Reactome Reaction: IRF7 → TRAF6 (indirect_complex) Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008, Konno et al., PloS one 2009
• WikiPathways Regulation of toll-like receptor signaling pathway: TRAF6 → IRF7 (activation)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): TRAF6 → IRF7 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: TRAF6 → IRF7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IRF7 — TRAF6 Kawai et al., Nat Immunol 2004
• IRef Bind_translation Interaction: IRF7 — TRAF6 (coimmunoprecipitation) Kawai et al., Nat Immunol 2004
• IRef Biogrid Interaction: TRAF6 — IRF7 (physical association, affinity chromatography technology) Kawai et al., Nat Immunol 2004
• IRef Biogrid Interaction: TRAF6 — IRF7 (physical association, affinity chromatography technology) Young et al., J Biol Chem 2011*
• IRef Biogrid Interaction: TRAF6 — IRF7 (physical association, affinity chromatography technology) Hu et al., J Immunol 2011*
• IRef Hprd Interaction: TRAF6 — IRF7 (in vivo) Kawai et al., Nat Immunol 2004
• IRef Innatedb Interaction: IRF7 — TRAF6 (unknown, -) Tun-Kyi et al., Nat Immunol 2011*
• IRef Innatedb Interaction: IRF7 — TRAF6 (unknown, -) Kawai et al., Nat Immunol 2004
• IRef Innatedb Interaction: IRF7 — TRAF6 (unknown, -) Ning et al., Mol Cell Biol 2008
• IRef Intact Interaction: IRF7 — TRAF6 (physical association, anti bait coimmunoprecipitation) Tun-Kyi et al., Nat Immunol 2011*

Text-mined interactions from Literome

Kawai et al., Nat Immunol 2004 : Furthermore, the adaptor molecule TRAF6 also bound and activated IRF7 ... Ubiquitin ligase activity of TRAF6 was required for IRF7 activation
Song et al., Proc Natl Acad Sci U S A 2008 : IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6 , but not TRAF2 or TRAF3 ... IRF7 activation required TRAF6 and RIP1, but not TRAF2 or TRAF3
Sirois et al., PloS one 2011 : Knocking down the expression of TRAF6 in macrophages increased HIV-1 replication and augmented the expression of IRF7 but not IRF3
Kitagawa et al., J Virol 2013 : These results demonstrate that binding of the V protein to IRF7 , IKKa, and MyD88 is largely indirect and mediated by endogenous TRAF6