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DST — IL4

Text-mined interactions from Literome

Lee et al., Immunology 2003 : In this study, we have examined the effects of BPA and NP on production of interleukin-4 (IL-4) , a pro-inflammatory cytokine closely associated with allergic immune responses ... Both BPA and NP significantly enhanced IL-4 production in keyhole limpet haemocyanin ( KLH ) -primed CD4+ T cells in a concentration dependent manner ... Furthermore, BPA and NP enhanced the activation of IL-4 gene promoter in EL4 T cells transiently transfected with IL-4 promoter/reporter constructs, and the enhancing effect mapped to a region in the IL-4 promoter containing binding sites for nuclear factor ( NF ) -AT ... Activation of T lymphocytes by phorbol 12-myristate 13-acetate/ionomycin resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of BPA or NP, as demonstrated by the electrophoretic mobility shift assay, indicating that the transcription factor NF-AT was involved in the enhancing effect of BPA and NP on IL-4 production ... The enhancement of IL-4 production by BPA or NP was significantly reduced by nitrendipine, a blocker of Ca2+ influx, and by FK506, a calcineurin inhibitor
Park et al., Immunol Invest 2010 : We also found that the phytoglycoprotein ( 75 kDa ) inhibits the release of histamine, and the expressions of cytokines ( IL-4 and IFN-gamma ) in the presence of BPA in RBL-2H3 cells