Bongalon et al., J Vasc Res 2004
:
Inhibition of ERK MAPKs ( U-0126, 10 muM ) or p38 MAPK ( PD-169316, 10 muM ), but not PI3Ks ( LY-294002, 50 muM ), reduced LIMK2 and cofilin gene expression stimulated by PDGF or IL-1beta
Gong et al., Angiogenesis 2004
:
Pharmacological inhibitors of phosphoinositide-3 kinase (PI3-K) and the rho activated kinase ( ROCK ) attenuated VEGF induced LIMK phosphorylation, indicating a role for ( PI3-K ) and ROCK in the signaling pathways leading to regulation of LIMK activity