◀ Back to IL12A
IL12A — IRF3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., J Exp Med 2003
:
Thus,
IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of
IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003
:
Both IFN-alpha and
IL-12 strongly
up-regulated IRF-1,
IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005
:
Furthermore,
IRF-8 induced
IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
Goriely et al., Blood 2006
:
Interferon regulatory factor 3 is
involved in Toll-like receptor 4 (TLR4)- and TLR3 induced
IL-12p35 gene activation ... Since IL-12p35 mRNA was induced in human DCs activated through TLR3 or TLR4 but not TLR2, we investigated the potential
role of
interferon regulatory factor 3 (IRF-3) in
IL-12p35 gene transactivation ... Finally, experiments on DCs from IRF-3-deficient mice established that TLR4 induced IL-12p35 mRNA and
IL-12p70 synthesis are
impaired in absence of
IRF-3
Aksoy et al., Blood 2007
:
Because
IRF-3 activity is also
required for
IL-12p70 synthesis, our findings provide a molecular basis for the decreased ability of LPS stimulated neonatal moDCs to elicit Th1-type responses