Yao et al., Biochem Biophys Res Commun 2004
(Down Syndrome) :
We show in this study that DSCR1 is greatly induced in endothelial cells in response to VEGF, TNF-alpha , and A23187 treatment, and that this up-regulation is inhibited by inhibitors of the calcineurin-NFAT ( nuclear factor of activated T cells ) signaling pathway as well as by PKC inhibition and a Ca ( 2+ ) chelator
Minami et al., J Biol Chem 2006
(Down Syndrome...) :
We recently reported that thrombin and vascular endothelial growth factor, but not tumor necrosis factor-alpha , results in dramatic up-regulation of Down syndrome critical region (DSCR)-1 gene in endothelial cells, a negative feedback regulator of calcineurin-NFAT signaling