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BCR — SOS1

Pathways - manually collected, often from reviews:

• BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOS1 — BCR (physical association, affinity chromatography technology) Puil et al., EMBO J 1994*
• IRef Biogrid Interaction: SOS1 — BCR (physical association, affinity chromatography technology) Maru et al., Mol Cell Biol 1995*

Text-mined interactions from Literome

Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : The adapter protein growth factor receptor binding protein-2 ( Grb2 ) can bind phosphorylated BCR/ABL-Y177 , induce Grb2-SoS complex formation and activate Ras signaling
Maru et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic) : Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS ... Tyrosine phosphorylation of BCR in v-fps transformed cells induced its association with GRB-2/SOS , the RAS guanine nucleotide exchange factor complex