◀ Back to ATR
ATR — RAD17
Pathways - manually collected, often from reviews:
-
BioCarta role of brca1 brca2 and atr in cancer susceptibility:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
Hus1/Rad1/Rad9/Rad17 complex (HUS1-RAD1-RAD9A-RAD17)
(modification, activates)
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
YWHAZ (YWHAZ)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
(modification, activates)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
YWHAZ (YWHAZ)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, activates)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
CHK1 (CHEK1)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CHK1 (CHEK1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN)
(modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/ATR/ATRIP complex (RPA1-RPA2-ATR-ATRIP)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP complex (RPA1-RPA2-ATR-ATRIP)
→
RPA/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Medhurst et al., J Cell Sci 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
CDC6 (CDC6)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CDC6 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CDC6 (CDC6)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Yoshida et al., J Cell Sci 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
TIMELESS/TIPIN complex (TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TIMELESS/TIPIN complex (TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Unsal-Kaçmaz et al., Mol Cell Biol 2007, Kemp et al., J Biol Chem 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CLASPIN (CLSPN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CLASPIN (CLSPN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-TIMELESS-TIPIN)
(modification, collaborate)
Wang et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TopBP1 (TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
TopBP1 (TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bao et al., Nature 2001, Zou et al., Genes Dev 2002, Kumagai et al., Cell 2006, Ball et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Mordes et al., Genes Dev 2008, Medhurst et al., J Cell Sci 2008, Vassin et al., J Cell Sci 2009, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
SMARCAL1 (SMARCAL1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
SMARCAL1 (SMARCAL1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/SMARCAL1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-SMARCAL1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/SMARCAL1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-SMARCAL1)
(modification, collaborate)
Bansbach et al., Genes Dev 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
CEP164 (CEP164)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database ATR signaling pathway:
CEP164 (CEP164)
→
RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1)
(modification, collaborate)
Sivasubramaniam et al., Genes Dev 2008
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ATR
—
RAD17
(direct interaction, enzymatic study)
Bomgarden et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
ATR
—
RAD17
(physical association, affinity chromatography technology)
Zhang et al., EMBO J 2010*
-
IRef Biogrid Interaction:
ATR
—
RAD17
(direct interaction, unspecified method)
Kim et al., J Biol Chem 1999
-
IRef Biogrid Interaction:
ATR
—
RAD17
(physical association, affinity chromatography technology)
Bao et al., Nature 2001
-
IRef Biogrid Interaction:
ATR
—
RAD17
(direct interaction, enzymatic study)
Bao et al., Nature 2001
-
IRef Hprd Interaction:
ATR
—
RAD17
(in vitro)
Kim et al., J Biol Chem 1999, Bao et al., Nature 2001
-
IRef Hprd Interaction:
ATR
—
RAD17
(in vivo)
Kim et al., J Biol Chem 1999, Bao et al., Nature 2001
Text-mined interactions from Literome
Bao et al., Nature 2001
:
ATR/ATM mediated phosphorylation of human
Rad17 is required for genotoxic stress responses ... Treatment of human cells with genotoxic agents induced
ATM/ATR dependent phosphorylation of
hRad17 at Ser 635 and Ser 645 ... These findings demonstrate that
ATR/ATM dependent phosphorylation of
hRad17 is a critical early event during checkpoint signalling in DNA damaged cells
Zhang et al., Mol Cell Biol 2005
:
Interference with the expression or the activity of PP5 leads to impairment of the
ATR mediated phosphorylation of
hRad17 and Chk1 after UV or hydroxyurea treatment