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FOS — NGF
Text-mined interactions from Literome
Tong et al., Neurochem Res 1999
:
While
NGF somewhat
increased c-Fos and c-Jun protein levels transiently, it had a more robust and persistent stimulatory effect on Jun B protein levels
Tanner et al., BJU Int 2000
(Urinary Bladder Diseases...) :
The expression of c-Fos was increased by phorbol 12-myristate 13-acetate added before NGF, suggesting that
c-Fos may be
involved in regulating
NGF production
Johansson et al., Eur J Neurosci 2000
(Brain Ischemia...) :
High concentrations of
nerve growth factor induced gene A and
c-Fos proteins were present within the region-at-risk even when cortical cerebral blood flow was as low as 40 % of control values
Vidal et al., J Cell Sci 2001
(MAP Kinase Signaling System) :
Gene trap analysis of germ cell signaling to Sertoli cells
: NGF-TrkA mediated induction of Fra1 and
Fos by post-meiotic germ cells ... Gene trap analysis of germ cell signaling to Sertoli cells :
NGF-TrkA mediated induction of Fra1 and
Fos by post-meiotic germ cells
Pflug et al., J Neurosci Res 2001
(Glioma) :
Moreover,
NGF increased
AP-1 binding activity in C6trk cells, suggesting that NGF may induce differentiation
Baskey et al., J Neurochem 2002
:
Transfection with an AP-1 luciferase reporter gene revealed that PC12 but not B5P cells expressed
nerve growth factor induced functional
AP-1 activity ... Using DNA-protein gel shift assays we determined that
nerve growth factor stimulates
AP-1 binding in both PC12 and B5P cells, and identified c-Fos, FosB, Fra-1, Fra-2, c-Jun, JunB and JunD in AP-1 complexes ... In Fos/Jun functional luciferase reporter assays,
nerve growth factor stimulated phosphorylation of
c-Fos in both PC12 and B5P cells, but phosphorylation of c-Jun only in PC12, and not in B5P cells
Ohki et al., Brain Res Dev Brain Res 2002
:
NGF mediated activation of the transcription factor
AP-1 was found to be suppressed in the NDRG4 protein diminished clone and enhanced in the NDRG4 protein upregulated clone as compared with those in the control cells ... These results suggest that NDRG4 plays a role in neurite outgrowth and has an influence on an
NGF stimulated
AP-1 activation by an undefined mechanism in PC12 cells
Oh et al., J Toxicol Environ Health 2004
:
Co-treatment of OTA with NGF resulted in inhibition of
NGF induced p38 MAP kinase and
AP-1 activation
Kamata et al., Arch Biochem Biophys 2005
:
Conversely, incubation of the cells with a reductant, N-acetyl-L-cysteine (NAC), inhibited
NGF induced neuronal differentiation and
AP-1 activation
Pizzio et al., Eur J Neurosci 2005
:
NGF activates
c-FOS and ERK1/2-MAPK in the suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during the day
Leugers et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
In addition, we demonstrate that Tau potentiates
AP-1 transcription factor activation in
response to
nerve growth factor (NGF)
Mullenbrock et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Expression of several
AP-1 family members was
induced by both EGF and
NGF , but their induction was more robust and sustained in response to NGF
Mocchetti et al., Proc Natl Acad Sci U S A 1989
(Astrocytoma) :
These data suggest that, in C6-2B astrocytoma cells, the nuclear accumulation of
c-Fos protein is
required for the induction of
NGF mRNA expression by BAR stimulation
Rauscher et al., Cell 1988
:
There is a dramatic increase in the FSE2 binding complex when
Fos levels are
induced with serum, benzodiazepine, and
nerve growth factor or are expressed from a v-fos gene
Peng et al., Brain Res 1993
:
Fos induction by
nerve growth factor in the adult rat brain
Kahle et al., J Neurochem 1994
:
H-7 reduced the
NGF induced expression of
c-Fos in a dose dependent manner without affecting the time course of c-Fos appearance ... Down-regulation of PKC activity by prolonged exposure to phorbol ester did not completely abolish the
effects of
NGF and H-7 on induction of
c-Fos , choline acetyltransferase activity, and neurite outgrowth, indicating that PKC independent pathways contribute to these actions
Colangelo et al., Brain Res Mol Brain Res 1996
(Glioma) :
Correlation between increased
AP-1NGF binding activity and
induction of
nerve growth factor transcription by multiple signal transduction pathways in C6-2B glioma cells ... All of these stimuli increased NGF mRNA levels within 3 h. Cycloheximide pretreatment blocked the TPA and ISO mediated binding to AP-1NGF suggesting that de novo synthesis of
c-Fos/c-Jun may be
required for the transcriptional regulation of
NGF gene
Tong et al., J Neurosci Res 1996
:
Effect of
nerve growth factor on
AP-1 , NF-kappa B, and Oct DNA binding activity in apoptotic PC12 cells : extrinsic and intrinsic elements
Kamata et al., J Biol Chem 1996
:
NAC suppressed
NGF induced c-fos gene expression and
AP-1 activation
Gibbs et al., Brain Res 1997
:
In these areas,
NGF mediated induction of
Fos-like immunoreactivity was detected as early as 3 h, peaked at 6 h, and was reduced by 12 h, postinfusion ... No evidence for an
NGF mediated induction of
Fos within parvalbumin containing neurons was detected in any of the four regions at any of the time-points examined ; however, evidence for an NGF mediated induction of Fos within epithelial cells lining the lateral ventricle was observed ... These data demonstrate that
NGF induces
Fos expression within cholinergic, and not parvalbumin containing ( GABAergic ), neurons in the basal forebrain, and furthermore that intracerebroventricular administration of NGF influences the different subgroups of basal forebrain cholinergic neurons to different degrees
Coffey et al., Neurosci Lett 1997
:
We find that BDNF but not
NGF rapidly ( within 2 h )
upregulates levels of synaptophysin, tau and
c-Fos correlating with expression of the neurotrophin receptor TrkB
Unlap et al., Biol Psychiatry 1997
:
Lithium attenuates
nerve growth factor induced
activation of
AP-1 DNA binding activity in PC12 cells ...
NGF induced large, time dependent
increases in
AP-1 DNA binding activity ... Pretreatment with 5 mmol/L lithium for 24 h reduced
AP-1 induction by
NGF by 42 % ; shorter treatments and lower concentrations of lithium had smaller inhibitory effects on AP-1
Furukawa et al., J Neurosci Res 1998
:
Induction of DNA binding activity of the transcription factor
AP-1 by
NGF was markedly suppressed in cells expressing mutant PS-1
Colangelo et al., Proc Natl Acad Sci U S A 1998
:
Our data suggest that, while
AP-1 may
regulate basal levels of
NGF expression, C/EBPdelta is a critical component determining the area-specific expression of NGF in response to BAR stimulation
Szeberényi et al., Mol Cell Biochem 1998
:
Normal
stimulation of the synthesis, phosphorylation and DNA binding activity of
c-Fos and Zif268 proteins by
nerve growth factor is not sufficient to mediate neuronal differentiation of PC12 cells ... To analyze the possible role of Ras and ERGs in neuronal differentiation, experiments were carried out to study the involvement of Ras proteins in the
NGF stimulated expression of two ERG coded proteins (
c-Fos and Zif268 ) implicated in NGF signaling
Cui et al., J Neurosci 1999
(Brain Ischemia) :
Our results demonstrate that c-fos antisense s-ODN blocks selected downstream events and support the contention that postischemic
Fos regulates the subsequent expression of the
NGF gene and that Fos expression may have a functional component in neuroregeneration after focal cerebral ischemia-reperfusion