◀ Back to FOXO1
FOXO1 — FOXO3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
FOXO1
→
FOXO3
(increases, FOXO1 Activity)
Modur et al., J Biol Chem 2002*
Evidence: Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of PTEN mutations in prostate cancer, we used microarrays to identify genes regulated by FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 p...
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OpenBEL Selventa BEL large corpus:
FOXO1
→
FOXO3
(increases, FOXO1 Activity)
Modur et al., J Biol Chem 2002*
Evidence: adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 prostate cancer cell line resulted in apoptosis and induced the expression of many genes The following comes from Table I.
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FastForward regulation:
FOXO1
→
FOXO3
(transcriptional regulation, increase)
Essaghir et al., J Biol Chem 2009*
Evidence: REG, PROMACTIVITY
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(transcription, inhibits)
Seoane et al., Cell 2004
Evidence: mutant phenotype, reporter gene, physical interaction
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NCI Pathway Database Class I PI3K signaling events mediated by Akt:
FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999, Kops et al., Nature 1999, Rena et al., J Biol Chem 1999, Brunet et al., J Cell Biol 2002
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database FoxO family signaling:
FOXO1-3a-4/beta catenin complex (FOXO3_FOXO4_FOXO1-CTNNB1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Essers et al., Science 2005
Evidence: physical interaction
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
→
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-FOXG1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Seoane et al., Cell 2004
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1-CEBPB)
→
SMAD2-3/SMAD4/FOXO1-3a-4 complex (SMAD2_SMAD3-SMAD4-FOXO3_FOXO4_FOXO1)
(modification, collaborate)
Gomis et al., Cancer Cell 2006
Evidence: physical interaction
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NCI Pathway Database Class I PI3K signaling events mediated by Akt:
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
→
FOXO1-3a-4 (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Kino et al., Diabetes 2005
(Acquired Immunodeficiency Syndrome...) :
This HIV-1 protein also interfered with insulin induced coprecipitation of 14-3-3 and Foxo3a in vivo and antagonized the negative effect of insulin on
Foxo3a induced transactivation of a
FOXO-responsive promoter
Lynch et al., Mol Cancer Res 2005
(Disease Progression...) :
Together, reduced
FOXO3a expression coupled to FOXO3a hyperphosphorylation would
suppress FOXO transcriptional activity
Essaghir et al., J Biol Chem 2009
:
The transcription of
FOXO genes is
stimulated by
FOXO3 and repressed by growth factors ... Conversely, ectopic
FOXO3 activation blocked the proliferation of fibroblasts and
induced the expression of FOXO1,
FOXO4 , and p27-KIP1 ... Conversely, ectopic
FOXO3 activation blocked the proliferation of fibroblasts and
induced the expression of
FOXO1 , FOXO4, and p27-KIP1 ... Using luciferase reporter assays and chromatin immunoprecipitations, we identified a conserved FOXO binding site in the promoter of the FOXO1 gene, which was required for regulation by PDGF, and mediated the
up-regulation of
FOXO1 by itself and by
FOXO3 ... Altogether, our results suggest that the expression of
FOXO1 and FOXO4 genes is
stimulated by
FOXO3 and possibly by other FOXO factors in a positive feedback loop, which is disrupted by growth factors
Zhou et al., Autophagy 2012
:
In this study, we showed that
FOXO3 induced a transcription dependent autophagy, and
FOXO1 was
required for this process ... Our data also showed that
FOXO3 overexpression did not
increase the expression of
FOXO1 at the protein level, although FOXO3 was capable of binding the promoter region of FOXO1 and inducing an increase in the transcription of FOXO1 mRNA ... Furthermore, our results showed that
FOXO3 promoted the translocation of
FOXO1 from the nucleus to the cytoplasm, resulting in an increase in FOXO1 induced autophagy