Gene interactions and pathways from curated databases and text-mining

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LIF — PI3

Text-mined interactions from Literome

Thabard et al., Cytokine 2001 (MAP Kinase Signaling System...) : In OPM-2 cells, IL-6, OSM and LIF induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI 3-K) activation
Hiraoka et al., Kobe J Med Sci 2003 (Cardiomyopathies...) : PI 3-kinase-Akt-p70 S6 kinase in hypertrophic responses to leukemia inhibitory factor in cardiac myocytes
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF , IL-1/IL-1R tI
Oh et al., J Biol Chem 1998 : We found that LIF induced the activation of PI 3-kinase in cardiac myocytes ... Moreover, JAK1 binds to PI 3-kinase, and LIF stimulation increases the PI 3-kinase activity in JAK1 immunoprecipitates