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ANGPT2 — IRS1
Text-mined interactions from Literome
Izawa et al., Exp Cell Res 2005
(Hypertension...) :
Ang II induced extracellular signal regulated kinase ( ERK ) 1/2 and c-Jun N-terminal kinase (JNK) activation and
IRS-1 phosphorylation at Ser307 and Ser616
Arellano-Plancarte et al., Biochem Pharmacol 2010
(Insulin Resistance) :
Studies with specific inhibitors of PI3K ( wortmannin ) and mTOR ( rapamycin ) revealed that
Ang II stimulates
IRS-1 phosphorylation of Ser ( 636 ) /Ser ( 639 ) via the PI3K/mTOR/S6K-1 pathway
Hitomi et al., Am J Physiol Cell Physiol 2011
(Hypertrophy...) :
We conclude that phosphorylation of Ser307, Ser302, and Ser632 of IRS-1 is not involved in ANG II-mediated IRS-1 degradation, and that JNK alone does not
mediate ANG II-stimulated IRS-1 degradation, but rather is responsible for the hypertrophic effects of insulin on smooth muscle