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HOXA11 — TP53

Text-mined interactions from Literome

Chu et al., Cancer Biol Ther 2004 (Breast Neoplasms...) : The mechanism by which estrogen and other estrogen receptor modulators influence both normal breast development as well as breast cancer may involve the regulation of developmental control genes such as HOXA10 ; HOXA10 in turn regulates expression of key downstream genes such as p53 and regulates tumor cell functional phenotype
Connell et al., Reprod Sci 2009 : HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments ... Based on these findings, we sought to determine if HOXA11 regulates p53 , a tumor suppressor gene which controls progression through the cell cycle and regulates ECM genes ... We have demonstrated that expression of HOXA11 represses expression of p53 , suggesting a mechanism by which HOXA11 regulates of the morphology and integrity of the USLs