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MAP2K3 — SMAD3

Pathways - manually collected, often from reviews:

• WikiPathways Endoderm Differentiation: MAP2K3 → SMAD3 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: SMAD3 — MAP2K3 (coimmunoprecipitation) Barrios-Rodiles et al., Science 2005
• IRef Ophid Interaction: SMAD3 — MAP2K3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ross et al., Cell Signal 2007 : SMAD3 expression is regulated by mitogen activated protein kinase kinase-1 in epithelial and smooth muscle cells ... Inhibition of mitogen activated protein kinase kinase-1 ( MEK1 ) with either PD98059 or UO126, however, results in a substantial dose dependent inhibition of SMAD3 promoter activity
Chen et al., Exp Cell Res 2010 : Inhibition of mitogen activated protein kinase kinase 1 ( MEK 1 ) either directly with PD98059 or with MEK 1 siRNA resulted in inhibition of EPO mediated suppression of EMT and Smad signal transduction in TGF-beta1 treated cells