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CCND1 — MIF
Text-mined interactions from Literome
Liao et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Adhesion mediated release of
MIF subsequently
promotes integrin dependent activation of MAP kinase,
cyclin D1 expression, and DNA synthesis
Swant et al., J Biol Chem 2005
(Cell Transformation, Neoplastic...) :
Rho GTPase dependent signaling is required for
macrophage migration inhibitory factor mediated expression of
cyclin D1 ... We now report that
MIF promotes the activation of the canonical ERK MAPK cascade and
cyclin D1 expression by stimulating the activity of the Rho GTPase and downstream signaling to stress fiber formation ... Our studies reveal that recombinant
MIF induces
cyclin D1 expression in a Rho-, Rho kinase-, MLC kinase-, and ERK dependent manner in asynchronous NIH 3T3 fibroblasts
Li et al., World J Gastroenterol 2009
(Stomach Neoplasms) :
To investigate the
effects of
macrophage migration inhibitory factor ( MIF ) on proliferation of human gastric cancer MGC-803 cells and expression of
cyclin D1 and p27 ( Kip1 ) in them, and further determine whether the effects are related to the PI3K/Akt signal transduction pathway ... Macrophage
MIF increases the proliferation of gastric cancer cells,
induces the expression of
cyclin D1 at the transcriptional level and inhibits the expression of p27 ( Kip1 ) at the post-transcriptional level via the PI3K/Akt pathway