UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CD4 — CLTA

Pathways - manually collected, often from reviews:

NCI Pathway Database Arf1 pathway: CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP complex (CD4-CLTA-COPA-CLTB-ARF1) → coatomer protein complex/ARF1/GTP complex (CLTA-COPA-CLTB-ARF1) (modification, collaborate)
NCI Pathway Database Arf1 pathway: CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP complex (CD4-CLTA-COPA-CLTB-ARF1) → CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex complex (CD4) (modification, collaborate)
NCI Pathway Database Arf1 pathway: coatomer protein complex/ARF1/GTP complex (CLTA-COPA-CLTB-ARF1) → CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex complex (CD4) (modification, collaborate)

Text-mined interactions from Literome

Gattinoni et al., Blood 2006 (Autoimmune Diseases...) : These results indicated that CD8 ( + ) CLTA-4 ( -/- ) T-cell mediated autoimmunity and tumor immunity required CD4 ( + ) T cells in which the function was dysregulated by the absence of CTLA-4 mediated negative costimulation
Hokey et al., J Med Primatol 2008 : CLTA-4 blockade enhanced CD4 ( + ) and CD8 ( + ) central memory ( CD28 ( hi ), CD95 ( hi ) ) T-cell responses as well as a short lived CD8 ( + ) effector ( CD28 ( lo ), CD95 ( hi ) ) T-cell response