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BRCA1 — HDAC2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
HDAC2
—
BRCA1
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Bind_translation Interaction:
HDAC2
—
BRCA1
(affinity chromatography technology)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Biogrid Interaction:
HDAC2
—
BRCA1
(direct interaction, pull down)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Biogrid Interaction:
HDAC2
—
BRCA1
(physical association, affinity chromatography technology)
Chang et al., Nat Med 2011*
-
MIPS CORUM BRCA1-HDAC1-HDAC2 complex:
BRCA1-HDAC1-HDAC2 complex complex (BRCA1-HDAC1-HDAC2)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Corum Interaction:
Complex of BRCA1-HDAC2-HDAC1
(association, anti tag coimmunoprecipitation)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Hprd Interaction:
HDAC2
—
BRCA1
(in vitro)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Hprd Interaction:
HDAC2
—
BRCA1
(in vivo)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Ophid Interaction:
HDAC2
—
BRCA1
(aggregation, confirmational text mining)
Yarden et al., Proc Natl Acad Sci U S A 1999*
-
IRef Ophid Interaction:
HDAC2
—
BRCA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Di et al., Nature structural & molecular biology 2010
:
Loss of
CtBP from the BRCA1 promoter through estrogen induction, depletion by RNA interference or increased NAD+/NADH ratio leads to HDAC1 dismissal, elevated histone acetylation and
increased BRCA1 transcription
Yu et al., J Biol Chem 1998
:
This finding suggests that
BRCA1 regulates gene expression, at least in part, by modulating
CtBP mediated transcriptional repression