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PTGS2 — SHBG
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Vanecková et al., Physiol Res 2005
(Body Weight...) :
The present study was performed to evaluate the
effects of sodium intake and of chronic
cyclooxygenase-2 (COX-2) inhibition on
systolic blood pressure (SBP) in heterozygous male transgenic rats harboring the mouse Ren-2 renin gene ( TGR ) and in transgene negative normotensive Hannover Sprague-Dawley ( HanSD )
Chen et al., Chem Res Toxicol 2012
(MAP Kinase Signaling System...) :
This
2-ABP induced
COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI ... Knocking down p22phox by siRNA significantly reduced
2-ABP induced
COX-2 expression ... Blocking the ERK/JNK-AP1 signaling pathways by pharmacological inhibitors attenuated
2-ABP induced
COX-2 expression ... Overexpression of the upstream ERK activator MEK1 significantly and consistently increased
2-ABP mediated
COX-2 expression ... Transfection of a dominant negative c-Jun mutant, TAM-67, blocked
2-ABP mediated
COX-2 expression, demonstrating that c-Jun was responsible for the transcriptional activation ... Taken together, these results demonstrate that
2-ABP induces the carcinogenic factor
COX-2 and that this induction is mediated through NADPH oxidase derived ROS dependent JNK/ERK-AP-1 pathways