Kishimoto et al., J Gastroenterol 2002
(Carcinoma...) :
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane
Lew et al., J Gastrointest Surg 2002
(Colorectal Neoplasms) :
Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive ... The reduction of intestinal neoplasia by APC gene replacement and COX-2 inhibition suggests their separate roles in intestinal tumorigenesis
Araki et al., Cancer Res 2003
:
COX-2 promoter luciferase activity is down-regulated by APC in a promoter reporter construct containing the, TBE but not with mutant TBE ... Taken together, our data support the hypothesis that COX-2 is down-regulated by APC and up-regulated by nuclear beta-catenin accumulation, and additionally implicate the Wnt signal transduction pathway in colon and liver carcinogenesis
Eisinger et al., Prostaglandins Other Lipid Mediat 2007
(Colonic Neoplasms) :
The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been demonstrated in vivo and has led to the hypothesis that APC regulates COX-2 expression ... This review will focus on the regulation of COX-2 by APC and the interplay between COX-2 and the Wnt signaling pathway
Bayorh et al., J Renin Angiotensin Aldosterone Syst 2012
:
Cyclooxygenase-2 (COX-2) levels were upregulated in the renal tubules and peritubular vessels after high-salt intake, and APC attenuated renal tubular COX-2 protein expression induced by ALDO