Koon et al., J Immunol 2006
:
Transient transfection with JAK2 short interferring RNA reduced COX-2 promoter activity and JAK2 phosphorylation, while RNA interference of STAT isoforms showed that STAT5 predominantly mediates SP-induced COX-2 promoter activity
Soto-Guzman et al., Prostaglandins Leukot Essent Fatty Acids 2013
(Breast Neoplasms) :
However, the role of OLA on Stat5 activation and the participation of COX-2 and LOXs activity in Stat5 activation induced by OLA remain to be investigated ... The Stat5 DNA binding activity requires COX-2 , LOXs, metalloproteinases and Src activities
Cao et al., Zhongguo Fei Ai Za Zhi 2013
(Adenocarcinoma...) :
STAT5 was required for COX-2 expression, but can mediated the effects of the COX-2 expression through pathways that were independent of transcriptional activation ... COX-2 expression is dependent on STAT5 phosphorylation