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ITGA3 — PTGS2

Text-mined interactions from Literome

Boosani et al., Blood 2007 (Neoplasms...) : We found that although both integrins were required for the inhibition of tube formation by alpha3 ( IV ) NC1 in endothelial cells, only alpha3beta1 integrin was sufficient to regulate COX-2 in hypoxic endothelial cells ... Furthermore, beta3 integrin-null endothelial cells, when treated with alpha3 ( IV ) NC1, inhibited hypoxia mediated COX-2 expression, whereas COX-2 inhibition was not observed in alpha3 integrin-null endothelial cells, indicating that regulation of COX-2 by alpha3 ( IV ) NC1 is mediated by integrin alpha3beta1
Mitchell et al., Cancer Res 2010 (Breast Neoplasms...) : Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells