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Tan et al., Endocrinology 2009 : In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling pathways ... Therefore, we investigated the effects of leptin on visfatin levels in 3T3-L1 adipocytes and human/murine AT, with or without a leptin antagonist ... Leptin significantly ( P < 0.01 ) increased visfatin levels in human and murine AT with a maximal response at leptin 10 ( -9 ) M, returning to baseline at leptin 10 ( -7 ) M. Importantly, ip leptin administration to C57BL/6 ob/ob mice further supported leptin induced visfatin protein production in omental AT ( P < 0.05 ) ... Furthermore, leptin induced visfatin production was significantly decreased in the presence of MAPK and phosphatidylinositol 3-kinase inhibitors ... Also, when the leptin receptor gene was knocked down using small interfering RNA, leptin induced visfatin expression was significantly decreased ... Thus, leptin increases visfatin production in AT in vivo and ex vivo via pathways involving MAPK and phosphatidylinositol 3-kinase signaling ... The pleiotropic effects of leptin may be partially mediated by visfatin
Ons et al., Domest Anim Endocrinol 2010 : We also studied the effect of leptin , cerulenin, and food deprivation, known effectors of energy balance and insulin action, on visfatin gene expression in chickens ... Also, the regulation of visfatin gene expression by leptin , cerulenin, and food deprivation is tissue specific
Hayes et al., Sleep 2011 : Leptin increased by 15 % ( P = 0.01 ) and visfatin increased by 31 % ( P = 0.05 ) for every 1-h decrease in REM sleep
Kang et al., Eur J Endocrinol 2011 (Amenorrhea...) : Animal and in vitro studies indicate that leptin alleviates starvation induced reduction in circulating vaspin and stimulates the production of visfatin ... Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte secreted hormonal regulators of metabolism are independently regulated in humans