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AHSA1 — LEP

Text-mined interactions from Literome

Kim et al., J Biol Chem 2003 : Leptin activated ERK, but not p38 and JNK, and up-regulated cPLA2 activity ; the latter was abolished by pre-treatment of cells with the MEK inhibitor ( PD98059 or U0126 ) or cPLA2 inhibitor ( AACOCF3 )
Cui et al., FASEB J 2006 : Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1
Mutabaruka et al., Arthritis Res Ther 2010 (Osteoarthritis) : Leptin also stimulated cell proliferation, and Erk 1/2 and p38 signaling
Garonna et al., PloS one 2011 : Inhibition of VEGFR2 tyrosine kinase activity reduced leptin stimulated p38 ( MAPK ) and Akt activation, COX-2 induction, and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo