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IL4 — RHOA

Text-mined interactions from Literome

Chiba et al., Pharmacol Res 2010 (Bronchial Hyperreactivity) : In the present study, the effects of IL-4 on the expression of RhoA protein, a monomeric GTP binding protein that contributes to the contraction of smooth muscle, were determined in cultured human bronchial smooth muscle cells ( hBSMCs ) ... IL-4 also caused a significant increase in the expression level of RhoA protein : the peak of the upregulation of RhoA protein was observed at 12-24h after the IL-4 treatment ... The RhoA upregulation induced by IL-4 , one of the Th2 cytokines upregulated in the airways of allergic bronchial asthmatics, might result in an augmentation of bronchial smooth muscle contractility, that is one of the causes of airway hyperresponsiveness
Gómez et al., Eur J Immunol 1997 : IL-2, but not IL-4 , induces Bcl-2 expression through RhoA activation which is inhibited by the specific Rho family inhibitor, Clostridium difficile Toxin B, as well as by a dominant negative RhoA mutant