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FZD4 — WNT1
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Melanogenesis:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Pathways in cancer:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
KEGG Basal cell carcinoma:
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
→
FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9
(protein-protein, activation)
-
Reactome Reaction:
FZD4
→
WNT1
(direct_complex)
Hsieh et al., Proc Natl Acad Sci U S A 1999, Mikels et al., PLoS Biol 2006
-
Reactome Reaction:
FZD4
→
WNT1
(reaction)
Hsieh et al., Proc Natl Acad Sci U S A 1999, Mikels et al., PLoS Biol 2006
-
WikiPathways ESC Pluripotency Pathways:
WNT3/WNT5B/WNT7A/WNT5A/WNT16/WNT10A/WNT7B/WNT2/WNT9B/WNT3A/WNT11/WNT4/WNT1/WNT6/WNT10B/WNT2B
→
Complex of 12 proteins
(activation)
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
WNT9B/WNT4/WNT7B/WNT10B/WNT5B/WNT2B/WNT3A/WNT16/WNT7A/WNT2/WNT11/WNT1/WNT6/WNT5A/WNT10A/WNT3
→
FZD8/FZD7/FZD5/FZD1/FZD6/FZD3/FZD2/FZD10/FZD9/FZD4
(activation)
-
WikiPathways Wnt Signaling in Kidney Disease:
WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B
→
FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3
(activation)
-
WikiPathways Wnt Signaling in Kidney Disease:
WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B
→
LRP5/LRP6/FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3
(activation)
Text-mined interactions from Literome
Swain et al., Cell communication and signaling : CCS 2005
:
It is not known how
FZD4S can
activate Wnt/beta-catenin signaling and what biological role this molecule plays in vivo
Tickenbrock et al., Int J Oncol 2008
(Leukemia, Myeloid, Acute) :
Activation of
Wnt signalling in acute myeloid leukemia by induction of
Frizzled-4
Junge et al., Cell 2009
:
TSPAN12 regulates retinal vascular development by promoting Norrin- but not
Wnt induced
FZD4/beta-catenin signaling
Gupta et al., Cancer Res 2010
(Prostatic Neoplasms) :
FZD4 as a mediator of ERG oncogene
induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells ... Taken together, our results provide mechanistic insights to ERG oncogenesis in prostate cancer, involving
activation of
WNT signaling through
FZD4 , leading to cancer promoting phenotypic effects, including EMT and loss of cell adhesion
Zhang et al., J Biol Chem 2011
(Osteoporosis...) :
In HEK293 transfection studies, C45Y, Y58C, and C204R mutants did not bind to Norrin and failed to transduce
FZD4 mediated
Wnt/ß-catenin signaling
Mössinger et al., EMBO Rep 2012
(Wnt Signaling Pathway) :
Itch directly associates with and ubiquitinates PI4KIIa, and both proteins colocalize on endosomes containing
Wnt activated
frizzled 4 (Fz4) receptor
Deng et al., J Cell Sci 2013
(Wnt Signaling Pathway) :
Norrin, the Norrie disease gene product, is also capable of activating
Wnt signaling
mediated by the
Frizzled4 receptor and serves as a BMP antagonist