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HSPB1 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HSPB1 → TNF (increases)
  Evidence: TNF-alpha induces the phosphorylation of HSP27 in HT-29 cells.

Text-mined interactions from Literome

De et al., J Immunol 2000 : Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus
Sheth et al., J Surg Res 2001 : Hsp 27 does not induce secretion of TNF-alpha , IL-10, or IL-12, whereas LPS does signal IL-12 and TNF-alpha secretion
Niwa et al., Eur J Pharmacol 2003 : Stimulation of neutrophils by TNF-alpha increased the levels of HSP27 in the presence, but not in the absence, of cycloheximide ... The HSP27 accumulation induced by TNF-alpha was significantly suppressed by 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( SB203580 ) or 4- ( 4-fluorophenyl ) -2- ( 4-nitrophenyl ) -5- ( 4-pyridyl ) -1H-imidazole ( PD169316 ) ; both are specific inhibitors of p38 MAP kinase, but not by 2'-amino-3'-methoxyflavone ( PD098059, a specific inhibitor of the upstream kinase that activates p44/p42 MAP kinase ) ... The accumulation of HSP27 induced by TNF-alpha plus cycloheximide was also suppressed by pretreatment with a specific protein kinase C ( PKC ) inhibitor ... p38 MAP kinase ( but not p44/p42 MAP kinase ) and PKC take part in TNF-alpha stimulated HSP27 induction in human neutrophils
König et al., Eur J Immunol 1991 : In view of the rapidity of the effect of TNF on the phosphorylation of HSP27 , it seems likely that the observed hyporesponsiveness reflects impairment of an early step in a signaling pathway, perhaps common to both the stimulation of phosphorylation and the induction of cell death by TNF
Niwa et al., Life Sci 2006 : Parallel to the decrease of HSP27, TNF-alpha increased the level of HSP27 in the incubation medium of the cells ... The decrease of HSP27 induced by TNF-alpha was suppressed by the pretreatment of PBMCs with the specific protein kinase C ( PKC ) inhibitor, GF109203X ... These results indicate that TNF-alpha reduces HSP27 in PBMCs through PKC activation
Nowis et al., Int J Cancer 2007 (Neoplasms, Experimental) : TNF prevented the upregulation of Hsp27 induced by bortezomib, which may contribute to enhanced ER stress
Hu et al., Gastroenterology 2007 (Colitis, Ulcerative...) : In young adult mouse colonic epithelial cells, IFN-gamma+TNF-alpha inhibited heat induction of Hsp25/27 and Hsp70, an effect not associated with changes in iHsp messenger RNA or protein half-lives but caused by suppressed de novo iHsp synthesis
Evans et al., Cell Signal 2008 : VEGF induced HSP27 phosphorylation at serines 15, 78 and 82, but whereas HSP27 phosphorylation induced by H2O2 and TNFalpha was completely blocked by the p38 kinase inhibitor, SB203580, VEGF stimulated serine 82 phosphorylation was resistant to SB203580 and small interfering ( si ) RNA mediated knockdown of p38 kinase and MAPKAPK2
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : TNF stimulation induced p38 MAPK dependent phosphorylation of MK2 and HSP27
Saklatvala et al., Biochem J 1991 : When cells had been depleted of protein kinase C ( PKC ) by prolonged treatment with PMA, stimulation by IL1, TNF or bradykinin still increased hsp 27 phosphorylation ... IL1, TNF and bradykinin each caused hsp 27 phosphorylation by a pathway independent of PKC
Mehlen et al., J Cell Biochem 1995 : Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27 , a stress protein that confers cellular resistance to this cytokine ... Here, we have analyzed the TNF-alpha mediated changes in the phosphorylation, cellular localization, and structural organization of hsp27 in HeLa cells ... We report that the TNF-alpha mediated hsp27 phosphorylation is a long lasting phenomenon that correlates with the cytostatic effect of this cytokine
Huot et al., Eur J Biochem 1995 : Induction of HSP27 kinase activity by TNF or H2O2 was completely inhibited by first treating the cells with the antioxidant N-acetyl-L-cysteine, suggesting that generation of reactive oxygen metabolites was the key triggering element of this induction
Guesdon et al., J Biol Chem 1993 : Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein
Beyaert et al., EMBO J 1996 : Pretreatment of cells with the highly specific p38 MAP kinase inhibitor SB203580 completely blocked this TNF induced activation of MAPKAP kinase-2 and hsp27 phosphorylation
Horman et al., Cell Prolif 1997 (Breast Neoplasms) : Our data show that TPA and TNF stimulate an immediate and massive phosphorylation of HSP27 , whereas OH-TAM affect the phosphorylation status of the protein only after a 3 day delay