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ERBB2 — TNF
Text-mined interactions from Literome
Yamaoka et al., Proc Natl Acad Sci U S A 2008
:
This study was undertaken to determine the
effects of
TNF on EGFR and
ErbB2 activation and intestinal epithelial cell survival ...
TNF also activated ErbB2, and loss of
ErbB2 expression
increased TNF induced apoptosis
Rivas et al., Breast Cancer Res Treat 2010
(Breast Neoplasms...) :
We found that
TNFalpha induces
ErbB-2 phosphorylation in mouse breast cancer C4HD cells and in the human breast cancer cell lines SK-BR-3 and BT-474 ...
ErbB-2 phosphorylation at Tyr877 residue was
mediated by
TNFalpha induced c-Src activation ... Moreover,
TNFalpha promoted
ErbB-2/ErbB-3 heterocomplex formation, Akt activation and NF-kappaB transcriptional activation ... Interestingly, our work disclosed that
TNFalpha is able to
transactivate ErbB-2 and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals
Kalthoff et al., Proc Natl Acad Sci U S A 1993
(Pancreatic Neoplasms) :
The inverse regulatory
effects of
TNF on
ERBB2 and EGFR mRNA levels were evoked by different signaling pathways of p55 TNF receptors ... In our study we show that the
TNF mediated down-regulation of
ERBB2 in pancreatic tumor cells is accompanied by an increase in growth inhibition at low doses of TNF