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IFNB1 — NOS2

Text-mined interactions from Literome

Diefenbach et al., Science 1999 (Leishmaniasis, Cutaneous) : Activation of Tyk2 in NK cells by IFN-alpha/beta also required NOS2
Yao et al., J Interferon Cytokine Res 2001 : Regulation by IFN-beta of inducible nitric oxide synthase and interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Hua et al., J Neurochem 2002 : In primary cultures of human astrocytes, we determined the effects of IFN-beta on astrocyte cytokine [tumor necrosis factor-alpha ( TNF-alpha ) and interleukin (IL)-6 ] and inducible nitric oxide synthase (iNOS) expression by ribonuclease protection assay and ELISA ... We found that IFN-beta inhibited astrocyte cytokine/iNOS induced by IL-1 plus IFN-gamma, but in the absence of IFN-gamma, IFN-beta enhanced IL-1 induced cytokine/iNOS expression
Utaisincharoen et al., Clin Exp Immunol 2004 (Melioidosis) : Induction of iNOS expression and antimicrobial activity by interferon (IFN)-beta is distinct from IFN-gamma in Burkholderia pseudomallei infected mouse macrophages
Zheng et al., J Biol Chem 2006 (Bone Resorption) : Thus, RANKL induced IFN-beta triggers iNOS/NO as an important negative feedback signal during osteoclastogenesis
Fujihara et al., J Biol Chem 1994 : The role of endogenous tumor necrosis factor alpha (TNF-alpha) and interferon-beta (IFN-beta) in lipopolysaccharide (LPS) induced activation of the inducible nitric-oxide synthase (i-NOS) gene was investigated ... These data thus suggest that endogenous IFN-beta , but not TNF-alpha, produced by LPS stimulated J774 cells specifically contributes , probably in an auto/paracrine fashion, to the activation of the i-NOS gene expression by LPS
Chen et al., Infect Immun 1996 : Further, exogenous IFN-beta potentiated iNOS mRNA expression in macrophages from young mice
López-Collazo et al., J Immunol 1998 : Evaluation of the transcriptional activity using run-on assays indicated that IFN-alpha/beta inhibited the transcription of iNOS ... These results suggest that in the presence of IFN-alpha/beta , the activity of the iNOS promoter is impaired, and this attenuated nitric oxide synthase expression could be important in pathophysiologic situations in which secretion of type I IFNs occurs