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CEACAM5 — IL10

Text-mined interactions from Literome

Jessup et al., Int J Cancer 2004 (Colorectal Neoplasms...) : Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells ... We hypothesized that CEA also stimulates the release of the antiinflammatory cytokine IL-10 causing inhibition of the toxicity of hepatic I/R injury and indirect stimulation of tumor cell colonization of the liver ... Thus, CEA stimulates production of IL-10 that may enhance metastasis by promoting the ability of circulating CRC cells to survive the I/R injury of implantation
Jessup et al., Clin Exp Metastasis 2004 (Colorectal Neoplasms...) : Since CEA induces release of IL-6 and IL-10 , we hypothesized that CEA inhibits the I/R injury through a Kupffer cell mediated cytokine dependent pathway