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EPHB2 — WAS
Text-mined interactions from Literome
Valjent et al., Eur J Neurosci 2001
(Synaptic Transmission) :
However, blockade of dopaminergic (DA) D1 receptors by administration of SCH 23390, prior to THC, totally prevents ERK activation in the striatum, thus demonstrating a critical involvement of DA systems in
THC induced
ERK activation ... DA-D2 and glutamate receptors of NMDA subtypes also participate, albeit to a lesser extent, to
THC induced
ERK activation in the striatum, as shown after injection of selective antagonists ( raclopride and MK801, respectively )
Upham et al., Int J Cancer 2003
(MAP Kinase Signaling System) :
Both Delta ( 9 )
-THC and CBN reversibly inhibited GJIC at noncytotoxic doses ( 15 microM ) in a normal diploid WB rat liver epithelial oval cell line within 20 min and
activated ERK1 and ERK2 within 5 min. Inhibition of MEK with PD98059 prevented the inhibition of GJIC by either cannabinoid, suggesting that inhibition of GJIC was MEK dependent
Derkinderen et al., J Neurosci 2003
:
In living mice,
THC activated
ERK in hippocampal neurons and induced its accumulation in the nuclei of pyramidal cells in CA1 and CA3
Cianferoni et al., J Allergy Clin Immunol 2005
(Wiskott-Aldrich Syndrome) :
These results suggest that
WASP is
essential for NF-ATp activation, and for nuclear translocation of
p-Erk , Elk1 phosphorylation, and c-fos gene expression in T cells
Rubino et al., Mol Neurobiol 2006
:
As a whole, our data suggest that in the striatum and cerebellum,
THC induced
ERK activation could represent a key signaling event to initiate homologous desensitization of CB1 receptor, accounting for the development of tolerance to THC induced hypolocomotion