Halls et al., Br J Pharmacol 2007
:
In contrast, RXFP3 and RXFP4 inhibit adenylate cyclase and RXFP3 causes ERK1/2 phosphorylation
van der Westhuizen et al., Mol Pharmacol 2007
:
Phospholipase Cbeta and the transactivation of endogenous epidermal growth factor receptors both played a role in RXFP3 mediated ERK1/2 activation in HEK293 cells ; however, they were not involved in RXFP3 mediated ERK1/2 activation in the CHO-K1 cell background
van der Westhuizen et al., Ann N Y Acad Sci 2009
:
RXFP3-GFP ( 2 ) activated ERK1/2 with a similar potency to RXFP3 when transiently expressed in CHO-K1 or HEK293T cells, suggesting that the GFP ( 2 ) tag did not affect receptor function