◀ Back to IL10

IL10 — SOCS3

Text-mined interactions from Literome

Ito et al., Blood 1999 : This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 ( SOCS3 )
Cassatella et al., Blood 1999 : Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils : evidence for an IL-10 induced pathway that is independent of STAT protein activation
Petit-Bertron et al., J Leukoc Biol 2003 : Tyk2 and signal transducer and activator of transcription 3 ( STAT3 ) phosphorylation and suppressor of cytokine signaling 3 ( SOCS3 ) expression were induced by IL-10 in both conditions, but a longer activation and/or expression were observed in adherent monocytes
Ding et al., J Immunol 2003 : It has been previously shown that IL-10 induced SOCS3 expression and that forced constitutive expression of SOCS3 inhibits IL-10/STAT3 activation and LPS induced macrophage activation ... Thus, the present results show that both SOCS1 and SOCS3 are induced by IL-10 and may be important inhibitors of both IL-10 and IFN-gamma signaling
Yasukawa et al., Nat Immunol 2003 : SOCS3 specifically prevents activation of STAT3 by IL-6 but not IL-10
Williams et al., J Immunol 2004 : Overexpression of STAT3 DN completely inhibited IL-10 induced suppressor of cytokine signaling 3 , tissue inhibitor of MMP-1, TNF receptor expression, and the recently identified IL-10-inducible genes, T cell protein tyrosine phosphatase and signaling lymphocyte activation molecule
Huang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005 : Endogenous IL-10 can induce high expression of SOCS3 and the SOCS3 is very important for regulating the signal transduction of the activities of T cells
Cassatella et al., Eur J Immunol 2005 : Activation of signal transducer and activator of transcription 3 ( STAT3 ) phosphorylation and induction of suppressor of cytokine signaling (SOCS)-3 protein by IL-10 are in fact negligible in circulating or freshly isolated ( `` time 0 '' ) neutrophils, but become readily measurable in neutrophils cultured for 4 h in the presence or absence of LPS
Qasimi et al., J Biol Chem 2006 : SOCS3 was essential for IL-10 inhibition of LPS stimulated production of iNOS ( inducible nitric-oxide synthase ) protein and nitric oxide ( NO )
Kinjyo et al., J Exp Med 2006 (Leishmaniasis, Cutaneous) : Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1
Cheon et al., J Immunol 2006 : Misoprostol, an EP2/3/4 agonist, and butaprost, an EP2 agonist, augmented IL-10 induced STAT3 phosphorylation and SOCS3 gene expression, but sulprostone, an EP1/3 agonist, had no effect
Dennis et al., Infect Immun 2006 (Lyme Disease) : Neither endogenous IL-10 nor the translation inhibitor cycloheximide blocked SOCS1/SOCS3 induction by B. burgdorferi and its lipoproteins, indicating that the expression of other genes is not required
Gleissner et al., Eur J Immunol 2007 : However, IL-10 stimulation resulted in up-regulation of SOCS-3 , a negative regulator of cytokine secretion, and induction of the inhibitory surface molecules immunoglobulin-like transcript 3 and 4 ( ILT3/ILT4 ) in EC, potentially involving glucocorticoid induced leucine zipper ( GILZ )
Qin et al., J Immunol 2007 (MAP Kinase Signaling System) : These results indicate that LPS induced MAPK activation, the production of endogenous IL-10 , and STAT-3 activation play critical roles in SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Tamassia et al., Int Immunol 2008 (Sepsis...) : Consequently, septic neutrophils are promptly responsive to IL-10 in vitro, as revealed by a direct IL-10 mediated induction of STAT3 tyrosine phosphorylation and SOCS-3 gene transcription, mRNA and protein expression
Dong et al., Placenta 2009 (Choriocarcinoma...) : In this study, we sought to determine if enhance SOCS-3 expression could affect IL-10 production in placental trophoblasts ... Our data suggested that enhanced SOCS-3 gene expression could promote IL-10 production by placental trophoblast cells, suggesting that SOCS-3 may play an important role in regulation of cytokine induced anti-inflammatory response in placental trophoblasts
Thompson et al., J Biol Chem 2009 : Interleukin-6, but not interleukin-10 , stimulated phosphorylation of STAT3, and induction of SOCS3 mRNA expression were potentiated in a time- and dose dependent manner in macrophage cell lines derived from AFABP/aP2-EFABP/mal1 double knock-out mice relative to cells from wild type animals
Ubol et al., J Infect Dis 2010 (Dengue) : High levels of IL-10 activated expression of suppressor of cytokine signaling 3 gene, which subsequently inactivated the Janus kinase-signal transducer and activator of transcription pathway ... Inhibition of IL-10 production by small interfering RNA down-regulated suppressor of cytokine signaling 3 gene expression, restored inducible nitric oxide synthase gene expression, and suppressed DENV replication
Nakaya et al., Int Immunol 2011 (Disease Progression...) : Forced expression of SOCS3 in T cells did not affect the production of the anti-inflammatory cytokines IL-10 and TGF-ß or that of the protective T ( h ) 1 type cytokine IFN-?, which is required for parasite clearance
Lewkowicz et al., Immunobiology 2013 : We showed that LPS activated Treg cells promote generation of IL-10 and TGF-ß1, inhibit IL-6 production by PMNs and induce the expression of heme oxygenase-1 (HO-1) and the suppressor of cytokine signaling 3 molecule ( SOCS3 )
Kleinsteuber et al., Blood 2012 (Tuberculosis) : SOCS3 promotes interleukin-17 expression of human T cells
Romain et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Aneurysm, Abdominal...) : Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 production and severe aortic aneurysm formation in mice -- brief report
Park et al., J Allergy Clin Immunol 2013 (Nasal Polyps...) : Nasal epithelial cell culture was used to elucidate the effect of IL-4, IL-5, IL-6, IL-10 , IL-13, IFN-?, TNF-a, and TGF-ß1 on SOCS1 and SOCS3 expression in sinus mucosa
Hokenson et al., PloS one 2013 : To support the idea that stretch induced SOCS3 expression via IL-6 leads to reduced IL-10 expression, siRNA mediated inhibition of SOCS3 restored IL-10 secretion in cells exposed to stretch and decreased IL-6 secretion