UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to HMGB1

HMGB1 — TIRAP

Pathways - manually collected, often from reviews:

NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → IRAK4 (IRAK4) (modification, collaborate) Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → IRAK (IRAK1) (modification, collaborate) Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) → HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → HMGB1/TLR4/MD2 (dimer) complex (TLR4-LY96-HMGB1) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer) complex (TLR4-LY96-HMGB1) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: MYD88/TIRAP complex (MYD88-TIRAP) → HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype