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MAPK1 — PLAT
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Son et al., Biochem Biophys Res Commun 2002
(MAP Kinase Signaling System) :
Soluble NCAM transiently inhibited
tPA mRNA expression levels in a
MAPK dependent manner, while stimulation of MAPK alone induced tPA reduction in cells ... In turn,
MAPK activation may
cause tPA degradation or a decrease in expression to promote synaptic plasticity
Kilic et al., Stroke 2005
(Brain Ischemia...) :
Western blots of ischemic brain lysates showed that
tPA markedly diminished eNOS levels,
increased extracellular regulated kinase
(ERK)-2 , and decreased MAP kinase/p38 activity ... In a mouse model of focal cerebral ischemia,
tPA induces eNOS inhibition,
ERK-2 activation, and p38 inhibition, possibly as part of a more complex signaling response exacerbating brain injury
Yang et al., Endocrine 2008
:
We have analyzed a possible
role of
mitogen activated protein kinase ( MAPK ) and activator protein-1 (AP-1) in the regulation of FSH induced tissue
type plasminogen activator (tPA) production in granulosa cells (GCs) prepared from DES treated immature rats ; Treatment of the cells in the presence of FSH with MAPK inhibitors, such as UO126 or SB203580, significantly decreased the FSH induced tPA production, suggesting that multiple signaling pathways may be involved in FSH regulated tPA expression
Armstead et al., Pediatr Crit Care Med 2011
(Toxoplasmosis, Cerebral) :
Red blood
cells-tissue plasminogen activator blocked c-Jun-N-terminal kinase but
potentiated p38
mitogen activated protein kinase upregulation after photothrombotic injury