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CD38 — EPHB2

Text-mined interactions from Literome

Zubiaur et al., J Biol Chem 2002 : Moreover, in these cells, anti-CD38 or anti-CD3 stimulation leads to protein kinase B/Akt and Erk activation, suggesting that the CD3-zeta-immunoreceptor tyrosine based activation motifs are not required for CD38 signaling in T cells ... Consistent with this, cholesterol depletion with methyl-beta-cyclodextrin substantially reduces CD38 mediated Akt activation while enhancing CD38 mediated Erk activation
Zumaquero et al., Exp Cell Res 2010 : Indeed, CD38 is enzymatically active in both exosomes and MR, and CD38 ligation induces Akt/PKB and Erk activation, which is accompanied by increased translocation of CD38 into MR. In conclusion, the present study indicates that CD38 localizes to MR, where it promotes cell signaling, and it is exported out of the cells through the exosome mediated exocytic pathway, where it may act as an intercellular messenger