Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
BID
→
GSK3B
(decreases, GSK3B Activity, BID Activity)
Evidence: GSK-3b activity restrains pro-apoptotic signaling from death receptors (ie, TNF-R1 {Official Gene Symbol: TNFRSF1A}, Fas, DR4 {Official Gene Symbol: TNFRSF10A}, DR5 {Official Gene Symbol: TNFRSF10B}).77?80 Inhibition of GSK-3b in the cells with activated death receptors enhanced activation of caspases-8 and -3, Bid cleavage and apoptosis, indicating that GSK-3b suppresses pro-apoptotic signals upstream of caspase activation.78?80 Thus, inactivation of GSK-3b under the condition of stimulation of...