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CXCR2 — IL8

Pathways - manually collected, often from reviews:

• KEGG Epithelial cell signaling in Helicobacter pylori infection: IL8 → CXCR1/CXCR2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: IL8 → CXCR2 (protein-protein, activation)
• KEGG Chemokine signaling pathway: CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, activation)
  
• Reactome Reaction: CXCR2 → IL8 (direct_complex) Walz et al., J Exp Med 1991*, Murphy et al., Science 1991*, Iida et al., Mol Cell Biol 1990*, Haskill et al., Proc Natl Acad Sci U S A 1990*, Holt et al., Biochemistry 1986*, Richmond et al., EMBO J 1988*, Poncz et al., Blood 1987*
• Reactome Reaction: CXCR2 → IL8 (reaction) Walz et al., J Exp Med 1991*, Lambert et al., Science signaling 2008, Murphy et al., Science 1991*, Iida et al., Mol Cell Biol 1990*, Haskill et al., Proc Natl Acad Sci U S A 1990*, Holt et al., Biochemistry 1986*, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Richmond et al., EMBO J 1988*, Poncz et al., Blood 1987*, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Suetomi et al., J Biol Chem 1999 : This study demonstrates that IL-8 recognizes and activates CXCR1, CXCR2 , and the Duffy antigen by distinct mechanisms
Williams et al., Arch Surg 1999 (Postoperative Complications...) : Flow cytometry and radioligand binding data indicate that IL-8 , GCP-2, and ENA-78 equivalently reduced CXCR-1 and CXCR-2 cell surface expression by 34 % to 54 %
Venkatakrishnan et al., J Biol Chem 2000 (Ovarian Neoplasms) : Stimulation of the CXCR-1/2 receptors by human interleukin 8 (IL-8) rapidly activated the p44/42 mitogen activated protein ( extracellular signal regulated kinase ( Erk1/2 ) ) kinase pathway
Zaslaver et al., J Immunol 2001 : Nocodazole, a microtubule disrupting agent, did not affect the IL-8 induced reduction in cell surface expression of CXCR1 and CXCR2 , nor did it affect the recycling of these receptors following ligand removal and cell recovery at 37 degrees C ... In contrast, cytochalasin D, an actin filament depolymerizing agent, promoted the IL-8 induced reduction in cell surface expression of both CXCR1 and CXCR2
Schraufstatter et al., Am J Physiol Lung Cell Mol Physiol 2001 : IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways ... These results indicate that IL-8 activates both the CXCR1 and the CXCR2 on microvascular endothelial cells, using different signal transduction cascades
Adams et al., J Trauma 2001 (Pneumonia...) : Such outcomes have been related to excess production of the CXC chemokine interleukin (IL)-8 , but PMN responses to IL-8 are mediated by both the relatively stable and IL-8 specific CXC receptor 1 (CXCR1) and the labile, promiscuous CXCR2
Puma et al., J Neurochem 2001 : Our results suggest that IL-8 release by glial cells in vivo may activate CXCR1 and CXCR2 receptors on cholinergic septal neurons and acutely modulate their excitability by closing calcium channels
Heidemann et al., J Biol Chem 2003 : Angiogenic effects of interleukin 8 ( CXCL8 ) in human intestinal microvascular endothelial cells are mediated by CXCR2
Feniger-Barish et al., Biochemistry 2003 (Inflammation) : CXCR1 and CXCR2 mediate migratory activities in response to IL-8 and other ELR+-CXC chemokines ( e.g., GCP-2 and NAP-2 )
Matheson et al., J Hum Genet 2006 (Respiratory Tract Diseases) : Cellular activity of IL8 is mediated by the receptor CXCR2 , and transcription of IL8 is controlled by the cytokine tumour necrosis factor ( TNFalpha )
Cohen-Hillel et al., Isr Med Assoc J 2007 : This over-phosphorylation of FAK was induced by IL-8 only when the receptor transmitting the chemokine signals was CXCR2 and not CXCR1, indicating that the two IL-8 receptors diverge in their signaling properties
Biju et al., Bioorg Med Chem Lett 2008 : A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-alpha and IL-8 mediated in vitro hPMN MPO release of CXCR2 and CXCR1 expressing cell lines
Hsieh et al., Rheumatology (Oxford) 2008 (Lupus Erythematosus, Systemic) : The IL-8 induced CXCR2 down-regulation in SLE-PMN was also impaired due to decreased proteolytic cleavage of IL-8-IL-8 receptor complexes from the cell surface whereas IL-8 induced internalization of the complexes was normal
Snoussi et al., BMC cancer 2010 (Breast Neoplasms...) : IL-8 acts through its CXCR1 and CXCR2 receptors