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ANK1 — SETD2
Text-mined interactions from Literome
Zaka et al., J Bone Miner Res 2009
:
Oxygen tension regulates the expression of
ANK ( progressive ankylosis ) in an
HIF-1 dependent manner in growth plate chondrocytes ... The data suggest that
ANK expression and function in vitro and in vivo are repressed in hypoxic environments and that the effect is
regulated by
HIF-1
Skubutyte et al., Arthritis Rheum 2010
(Calcinosis) :
Transfections were performed to determine the
effect of
HIF-1/2 on
ANK promoter activity ... However, silencing of
HIF-1a and HIF-2a
resulted in increased
ANK expression and up-regulation of promoter activity ... Overexpression of
HIF-1a and HIF-2a in nucleus pulposus cells
resulted in a significant suppression of
ANK promoter activity