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HDAC1 — HSPA5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM HCF-1 complex: HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1) Wysocka et al., Genes Dev 2003
• IRef Corum Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009

Text-mined interactions from Literome

Shi et al., Bioorg Med Chem Lett 2007 : Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition
Baumeister et al., Mol Cancer Ther 2009 : Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor induced apoptosis ... Our studies reveal that HDAC inhibitors specifically induce GRP78 , and the induction level is amplified by ER stress ... We show the involvement of HDAC1 in the negative regulation of the Grp78 promoter not only by its induction in the presence of the HDAC inhibitors trichostatin A and MS-275 but also by exogenous overexpression and small interfering RNA knockdown of specific HDACs