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IRF6 — MIPEP
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Xavier et al., Am J Respir Cell Mol Biol 1999
:
To investigate whether LPS induced TNF-alpha release is related to other inflammatory mediators from the same cell type, we examined
effects of
LPS stimulation on
macrophage inflammatory protein (MIP)-2 production by alveolar epithelial cells, and then examined the relationship between TNF-alpha and MIP-2 production ... These results suggest that
LPS induced
MIP-2 release from alveolar epithelial cells may be mediated in part by TNF-alpha from the same cell type
Olszyna et al., J Infect Dis 2000
(Endotoxemia) :
Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on
LPS induced production of
macrophage inflammatory protein (MIP)-1alpha , MIP-1beta, and monocyte chemoattractant protein (MCP)-1
Liaudet et al., Ann Surg 2002
(Disease Models, Animal...) :
Inosine downregulated the
LPS induced expression of TNF-alpha, IL-1beta, IL-6 and
MIP-2 and tended to reduce MIP-1alpha, whereas it enhanced the production of IL-4
Calkins et al., J Endotoxin Res 2002
(Disease Models, Animal...) :
In summary,
LPS induces IL-1beta and
MIP-2 expression in the lung and liver, both of which are IL-1 dependent
Menten et al., J Leukoc Biol 2002
(Disease Models, Animal...) :
Moreover, upon
stimulation with
lipopolysaccharide (LPS) or virus, ESb-MP cells themselves produce significant amounts of
MIP-1 ( approximately 200 ng/ml )
Kim et al., Mol Immunol 2003
:
We show here that the
MIP-2 promoter is transcriptionally
activated in a macrophage cell line RAW 264.7 by
LPS through a sequence located between -450 and -54 and this region contains two copies of activator protein-1 (AP-1) and one copy of nuclear factor-kappaB (NF-kappaB) binding site
Uchiyama et al., Clin Exp Pharmacol Physiol 2004
(Respiratory Distress Syndrome, Adult) :
Furthermore, TMG attenuated the
LPS induced increase in pulmonary expression of KC,
MIP-1alpha and MCP-1 at both the transcriptional and translational levels
Ellaban et al., Cell Immunol 2004
(Cecal Diseases...) :
Production of IL-10 and the IL-1 receptor antagonist,
MIP-2 , and MCP-1 in
response to
LPS stimulation was equivalent to the amount produced by naive macrophages
Lucchi et al., J Reprod Immunol 2007
:
LPS induced time dependent expression and secretion of IL-8,
macrophage inflammatory protein (MIP)-1alpha and MIP-1beta from ST cells and an upregulation of ICAM-1
Yeh et al., Life Sci 2007
(Edema...) :
Hesperidin downregulate the
LPS induced expression of TNF-alpha, IL-1 beta, IL-6, KC,
MIP-2 , MCP-1, and IL-12
Sha et al., Eur J Pharmacol 2007
(Disease Models, Animal...) :
Intravenous administration of TAK-242 to mice 1 h before LPS challenge dose-dependently inhibited
LPS induced increases in serum levels of TNF-alpha, IL-1beta, IL-6, IL-10,
MIP-2 , and NO metabolites
Martin et al., Cell Immunol 1991
:
In contrast, PGE1 inhibits
LPS induced JE,
MIP-1 alpha, and MIP-1 beta mRNA expression and this inhibition is partially dependent on a cAMP mediated pathway of signal transduction
Berchtold et al., BMC immunology 2008
:
By using stably transfected RAW264.7 macrophages overexpressing IFIT-2 we found that IFIT-2 inhibits selectively
LPS induced expression of TNF-alpha, IL-6, and
MIP-2 but not of IFIT-1 or EGR-1
Moon et al., Respir Res 2009
(Acute Lung Injury...) :
A pretreatment with RGDS inhibited
LPS induced increases in neutrophil and macrophage numbers, total protein levels and TNF-alpha and
MIP-2 levels, and matrix metalloproteinase-9 activity in bronchoalveolar lavage (BAL) fluid at 4 or 24 h post-LPS treatment
Arranz et al., Age (Dordrecht, Netherlands) 2010
(Inflammation) :
Chemokine responses in regard to KC, MCP-1, MIP1ß, and RANTES were more variable, though similar secretion of
LPS induced KC and MCP-1 and ConA induced MCP-1,
MIP-1ß , and RANTES was found in long lived and middle aged mice
Larmonier et al., Inflamm Bowel Dis 2011
(Disease Models, Animal) :
Curcumin attenuated
lipopolysaccharide (LPS) stimulated expression and secretion of
macrophage inflammatory protein (MIP)-2 , interleukin (IL)-1ß, keratinocyte chemoattractant ( KC ), and MIP-1a in colonic epithelial cells ( CECs ) and in macrophages
Lee et al., J Nutr Biochem 2011
:
Enzyme linked immunosorbent assay results showed that
lipopolysaccharide (LPS) induces the expression of monocyte chemotactic protein-1 (MIP-1), tumor necrosis factor-a, stromal cell derived factor-1, and
MIP-1a , and this induction may be repressed by GBE treatment due to TLR4 blockade
Trummer-Menzi et al., Pediatric pulmonology 2012
(Disease Models, Animal...) :
At T : 0 hr,
LPS + MV + O ( 2 )
increased gene expression of pro-inflammatory
MIP-2
Weinberger et al., Neonatology 2013
(Hyperbilirubinemia, Neonatal...) :
Bilirubin increased basal production of IL-8 and IL-1ß, but downregulated
LPS induced generation of IL-8 and
MIP-1ß
Sakai et al., Cytokine 1997
:
These data suggest that
MIP-2 might be
induced by a direct effect of
LPS and in part indirect one via initial induction of other cytokines such as TNF-alpha, leading a tendency of biphasic pattern
Ishii et al., J Neurooncol 1998
(Astrocytoma...) :
However,
MIP-1alpha production was
increased in three cell lines by stimulation with
lipopolysaccharide (LPS) and 5 cell lines by stimulation with phorbol-12myristate-13-acetate ( PMA )