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IL10 — TNFSF11
Text-mined interactions from Literome
Park et al., Exp Mol Med 2005
:
In addition,
RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of
IL-10 , IL-12, IFN-gamma, and iNOS
Liu et al., Eur J Oral Sci 2006
(Alveolar Bone Loss) :
Interleukin-10 enhanced the expression of OPG and
down-regulated the expression of
RANKL and CSF-1
Ernst et al., Clin Exp Immunol 2007
(Bone Resorption...) :
Finally,
IL-10 suppressed both soluble
RANKL ( sRANKL ) and membrane RANKL ( mRANKL ) expression by peripheral blood mononuclear cells ( PBMC ) activated in vitro in a bacterial antigen-specific manner
Zheng et al., Biochem Pharmacol 2013
(Bone Resorption) :
Coumermycin A1 also abrogated
RANKL induced expression of
interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments