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NDP — TNF
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Colombo et al., Shock 2007
(Inflammation...) :
Bleomycin induced expression of proinflammatory and profibrotic factors ( interleukin 6,
tumor necrosis factor-alpha , transforming growth factor-beta1, and inducible nitric oxide synthase ) and chemokines ( chemokine [C-C motif] ligand 2 and chemokine [C-C motif] ligand 5 ) was likewise significantly
reduced by
NDP-alpha-MSH
Bitto et al., Br J Pharmacol 2011
(Multiple Organ Failure) :
At day 7, in the liver and lung NDP-a-MSH, significantly reduced mRNA expression of
tumour necrosis factor-a (TNF-a) , increased mRNA expression of interleukin-10 and improved the histological picture, as well as reduced TNF-a plasma levels ; furthermore,
NDP-a-MSH dose-dependently
increased survival rate, as assessed throughout the 16 day observation period
Minutoli et al., Endocrinology 2011
(Inflammation...) :
NDP-a-MSH inhibited IL-6 and
TNF-a expression, decreased histological damage, and increased neural efferent activity
Figueiredo et al., Naunyn Schmiedebergs Arch Pharmacol 2013
(Peritonitis) :
NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and
reduced peritoneal macrophage inflammatory protein 2, but not
TNF-alpha , IL-1beta, IL-10, and keratinocyte derived chemokine production