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AKT3 — PTPN2
Text-mined interactions from Literome
Galic et al., Mol Cell Biol 2005
:
Consistent with this, suppression of
TCPTP protein levels by RNA interference in PTP1B-/- MEFs resulted in no change in ERK1/2 signaling but
caused prolonged
Akt activation and Y1162/Y1163 phosphorylation
Brenndörfer et al., Hepatology 2009
:
CONCLUSION : This down-regulation of
TC-PTP results in an enhancement of epithelial growth factor (EGF) induced signal transduction and
increases basal activity of
Akt , which is demonstrated to be essential for the maintenance of sufficient viral replication