Gene interactions and pathways from curated databases and text-mining

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AKT3 — P2RY12

Text-mined interactions from Literome

Soulet et al., Journal of thrombosis and haemostasis : JTH 2004 (MAP Kinase Signaling System) : The P2Y12 mediated stimulation of proliferation required the pertussis toxin-sensitive activation of PI3-kinase/Akt upstream of MAP-kinases
Ding et al., Mol Pharmacol 2006 : The constitutively active P2Y(12) mutant caused Akt phosphorylation that was abolished by the addition of pertussis toxin
Reséndiz et al., Journal of thrombosis and haemostasis : JTH 2007 : Akt phosphorylation approximately 60 s after PAR1 stimulation became entirely dependent on the purinergic receptor P2Y(12) and the activation of PI3K
Irino et al., J Neurosci Res 2008 : Akt activation is involved in P2Y12 receptor mediated chemotaxis of microglia
Xiang et al., Journal of thrombosis and haemostasis : JTH 2010 : We used P2Y1 knockout mice to address the role of P2Y12 in Akt phosphorylation in response to thrombin receptors in platelets