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AKT2 — AKT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Peng et al., Genes Dev 2003
(Abnormalities, Multiple...) :
Specifically, Akt1 and
Akt2 are
required for the induced expression of PPARgamma, the master regulator of adipogenesis, establishing a new essential role for
Akt in adipocyte differentiation ... These functions of Akt were uncovered despite the observed lower level of
Akt activity
mediated by
Akt3 in Akt1/Akt2 DKO cells, suggesting that a critical threshold level of Akt activity is required to maintain normal cell proliferation, growth, and differentiation
Tokuda et al., Hum Mol Genet 2011
(Disease Susceptibility...) :
An in vitro kinase assay revealed that Akt3 ( Nmf350 ) confers higher enzymatic activity, suggesting that
Akt3 ( Nmf350 ) might
enhance AKT signaling in the brain
Huang et al., Cardiovasc Drugs Ther 2011
(Disease Models, Animal...) :
LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor ( Rp-cAMPS ) or
Akt-inhibitor (
AKT 1/2 kinase
inhibitor )
Hanrahan et al., Cancer Discov 2012
(Cystadenocarcinoma, Serous...) :
Inhibition of AKT1 caused growth arrest in a subset of ovarian cell lines, but not in those with
AKT3 expression, which
required pan-AKT inhibition