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PRIMA1 — TP53

Text-mined interactions from Literome

Demma et al., J Biol Chem 2004 : In a similar assay PRIMA1 does not have any effect on p53 core DNA binding activity
Liang et al., J Steroid Biochem Mol Biol 2005 (Breast Neoplasms...) : PRIMA-1 induced p53 protein in the HCC-1428 cells while levels of mutant p53 protein in T47-D and BT-474 remained unaltered
Rehman et al., Breast Cancer Res 2005 (Breast Neoplasms) : We previously reported that PRIMA-1 ( for ` p53 reactivation and induction of massive apoptosis ' ) restored the transcriptional activity of p53 target genes in breast cancer cells with a p53 mutation ... The studies demonstrate that PRIMA-1 restores the p53-Hsp90alpha interaction, enhances the translocation of the p53-Hsp90alpha complex and reactivates p53 transcriptional activity
Cory et al., Anticancer Res 2006 (Leukemia L1210...) : Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53 : necrosis vs. apoptosis
Rökaeus et al., Oncogene 2007 : PRIMA-1 ( MET ) induces nucleolar accumulation of mutant p53 and PML nuclear body associated proteins
Shi et al., Carcinogenesis 2008 (Carcinoma, Hepatocellular...) : In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249
Stuber et al., Molecular cancer 2009 (Cell Transformation, Viral) : We have previously shown that PRIMA-1MET induces nucleolar translocation of p53 , PML, CBP and Hsp70
Lambert et al., Oncogene 2010 : Genes affected by PRIMA-1 ( MET ) in a mutant p53 dependent manner include the cell-cycle regulators GADD45B and 14-3-3gamma and the pro-apoptotic Noxa
Russo et al., Biochim Biophys Acta 2013 (Neoplasms) : We previously found that in the MDA-MB-231 cell line expressing high level of the mutant p53-R280K protein, PRIMA-1 induced p53 ubiquitination and degradation associated to cell death